After England and Wales both recorded resounding wins at the weekend over Italy and Scotland respectively, the pair will meet at Twickenham on Saturday afternoon.
It could prove to be a pivotal game in deciding who is crowned champions in March, and the game has thrown up some classics over the years.
We take a look at the last five meetings between the two teams in the Six Nations.
11/02/17: Wales 16 – 21 England
Having kicked off their Six Nations campaign with a 19-16 win over France, England travelled to face a Welsh side coming off a 33-7 win away to Italy.
Leigh Halfpenny opened the scoring with a penalty in the second minute, before Owen Farrell hit back with one of his own before a Ben Youngs try put England 8-3 up.
Ten unanswered Welsh points, including a Liam Williams try, meant Wales went into half-time 13-8 ahead.
Warren Gatland’s side led 16-11 heading into the final 10 minutes, before a Farrell penalty and a converted Elliot Daly try gave England a last-gasp 21-16 victory.
England went on to win the competition, but suffered a 13-9 defeat to Ireland in their final game in Dublin.
12/03/16: England 25 – 21 Wales
England came into the game off the back of three consecutive wins over Scotland, Italy and Ireland, while Wales had drawn away to Ireland and recorded home victories over Scotland and France.
They stormed into a 16-0 lead at half-time, with 11 points from the boot of Owen Farrell and an Anthony Watson try.
Wales would stage a stunning late bid for victory, with a Dan Biggar try followed by converted scores from George North and Talupe Faletau in the last 10 minutes.
Three second-half Farrell penalties kept the Welsh at bay and meant England travelled to France with the possibility of completing the Grand Slam.
They duly obliged, with tries from Danny Care, Dan Cole and Anthony Watson sealing a 31-21 victory.
06/02/15: Wales 16 – 21 England
The 2015 Six Nations kicked off with a Friday night fixture at the Millennium Stadium.
George Ford was named man of the match after amassing 11 points, with Anthony Watson and Jonathan Joseph scoring tries.
Warren Gatland’s side scored all of their 16 points in the first half, with Rhys Webb’s try converted by Leigh Halfpenny, adding to his two penalties and Dan Biggar’s drop goal.
Wales went on to record four victories in a row, while England were only beaten 19-9 away to Ireland.
Ireland won the title on points difference, having scored six more points than England and 10 more than Wales.
09/03/14: England 29 – 18 Wales
Matchday Four saw Wales travel to Twickenham, looking to keep their slim title hopes alive after they had been beaten 26-3 by Ireland.
England had also suffered defeat, going down 26-24 to France after a late converted Gael Fickou try.
First-half converted tries from Danny Care and Luther Burrell, combined with two Owen Farrell penalties, put England into a commanding lead.
Six penalties from the boot of Leigh Halfpenny wasn’t enough to avoid a 29-18 defeat for the Welsh, and they eventually finished third in the standings.
Ireland beat England to the title on points difference, with Jonny Sexton finishing the tournament as top points scorer.
16/03/13: Wales 30 – 3 England
England and Wales both entered the final week in Cardiff knowing a win would seal the Six Nations title.
Stuart Lancaster’s side came into the match unbeaten, including an impressive 12-6 victory in Dublin against Ireland.
Wales’ only loss came in the first week, going down 30-22 to Ireland in Cardiff.
With the score at 9-3 going into half-time, two second-half tries from Alex Cuthbert helped Wales run away with the match and lift the title.
Leigh Halfpenny, who scored 74 points during the competition, was named player of the tournament.